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Article

Modulation of the human ρ1 GABAA receptor by inhibitory steroids.

Psychopharmacology - 1 Sept 2014

Eaton Megan M, Lim You Bin, Covey Douglas F, Akk Gustav

Abstract excerpt

RATIONALE: Modulators of the ρ1 GABAA receptor may be useful in the treatment of visual, sleep, and cognitive disorders. Neuroactive steroids and analogues have been shown to modulate ρ1 receptor function, but the molecular mechanisms are poorly understood. OBJECTIVES: We employed electrophysiology and voltage-clamp fluorometry to compare the actions of several neuroactive steroids and analogues on the human ρ1...

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Identifiers

PMID: 24317445
DOI: 10.1007/s00213-013-3379-z
PMCID: PMC4048647

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