Article
Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomy.
Breast cancer research and treatment - 1 Jun 2010
Pierce Lori J, Phillips Kelly-Anne, Griffith Kent A, Buys Saundra, Gaffney David K, Moran Meena S, Haffty Bruce G, Ben-David Merav, Kaufman Bella, Garber Judy E, Merajver Sofia D, Balmaña Judith, Meirovitz Amichay, Domchek Susan M
Abstract excerpt
Women with BRCA1 and BRCA2 mutations have an elevated risk of breast cancer and ovarian cancer, but also of developing second primary breast cancer. BRCA1/2 mutation carriers with breast cancer must choose between breast conservation (BCT) and mastectomy (M) yet data on outcomes are limited. The purpose of this study is to compare long-term outcome following BCT and M in BRCA1/2 carriers. 655 women with BRCA1/2...
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