Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac239Deltanef.

doi:10.1128/JVI.79.8.4886-4895.2005

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Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac239Deltanef.

Journal of virology - 1 Apr 2005

Kim Eun-Young, Busch Marc, Abel Kristina, Fritts Linda, Bustamante Patty, Stanton Jenny, Lu Ding, Wu Samuel, Glowczwskie Jenny, Rourke Tracy, Bogdan Derek, Piatak Mike, Lifson Jeffrey D, Desrosiers Ronald C, Wolinsky Steven, Miller Christopher J

Abstract excerpt

To characterize the occurrence, frequency, and kinetics of retroviral recombination in vivo, we intravaginally inoculated rhesus macaques, either simultaneously or sequentially, with attenuated simian immunodeficiency virus (SIV) strains having complementary deletions in their accessory genes and various degrees of replication impairment. In monkeys inoculated simultaneously with SIVmac239Deltavpx/Deltavpr and...

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PMID: 15795274
DOI: 10.1128/JVI.79.8.4886-4895.2005
PMCID: PMC1069535

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Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac239Deltanef.PMID 15795274Read ↗

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