Article
Persistent infection with SIVmac chimeric virus having tat, rev, vpu, env and nef of HIV type 1 in macaque monkeys.
AIDS research and human retroviruses - 1 Aug 1994
Igarashi T, Shibata R, Hasebe F, Ami Y, Shinohara K, Komatsu T, Stahl-Hennig C, Petry H, Hunsmann G, Kuwata T
Abstract excerpt
A chimeric human and simian immunodeficiency virus carrying the tat, rev, vpu, env, and nef genes of human immunodeficiency virus type 1 was generated. The chimeric virus, NM-3n, grew competently in peripheral blood mononuclear cells from cynomolgus monkeys like the parental SIVmac. Two cynomolgus monkeys and one rhesus monkey inoculated with NM-3n raised antibodies to SIVmac Gag and HIV-1 Env. The antibodies...
Topics
- Animals
- Antibodies, Viral
- Base Sequence
- Carrier State
- Cells, Cultured
- DNA, Viral
- Female
- Gene Products, gag
- Genes, Viral
- Genes, nef
- HIV Envelope Protein gp120