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Functional Roles of the IgM Fc Receptor in the Immune System

3 May 2019

Abstract excerpt

It is now evident from studies of mice unable to secrete IgM that both non-immune “natural” and antigen-induced “immune” IgM are important for protection against pathogens and for regulation of immune responses to self-antigens. Since identification of its Fc receptor (FcµR) by a functional cloning strategy in 2009, the roles of FcµR in these IgM effector functions have begun to be explored. Unlike Fc receptors...

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Identifiers

PMID: 31130948
DOI: 10.3389/fimmu.2019.00945

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