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Article

Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1

15 Jan 2016

Abstract excerpt

Plasmodium falciparum virulence is associated with sequestration of infected erythrocytes. Microvascular binding mediated by PfEMP1 in complex with non-immune immunoglobulin M (IgM) is common among parasites that cause both severe childhood malaria and pregnancy-associated malaria. Here, we present cryo-molecular electron tomography structures of human IgM, PfEMP1 and their complex. Three-dimensional...

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PMID: 26776517
DOI: 10.1016/j.celrep.2015.12.067

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