Article
Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes.
The Journal of biological chemistry - 28 Jan 2005
Johansson Eva, Fanø Mathias, Bynck Julie H, Neuhard Jan, Larsen Sine, Sigurskjold Bent W, Christensen Ulla, Willemoës Martin
Abstract excerpt
dCTP deaminase (EC 3.5.4.13) catalyzes the deamination of dCTP forming dUTP that via dUTPase is the main pathway providing substrate for thymidylate synthase in Escherichia coli and Salmonella typhimurium. dCTP deaminase is unique among nucleoside and nucleotide deaminases as it functions without...
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