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Article

Bestrophin Cl- channels are highly permeable to HCO3-.

American journal of physiology. Cell physiology - 1 Jun 2008

Qu Zhiqiang, Hartzell H Criss

Abstract excerpt

Bestrophin-1 (Best1) is a Cl(-) channel that is linked to various retinopathies in both humans and dogs. Dysfunction of the Best1 Cl(-) channel has been proposed to cause retinopathy because of altered Cl(-) transport across the retinal pigment epithelium (RPE). In addition to Cl(-), many Cl(-) channels also transport HCO3(-). Because HCO3(-) is physiologically important in pH regulation and in fluid and ion...

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Identifiers

PMID: 18400985
DOI: 10.1152/ajpcell.00398.2007
PMCID: PMC2465210

Genes

RPE

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