Article
Acetylcholine induces cytosolic Ca2+ mobilization in isolated distal colonic crypts from normal and cystic fibrosis mice.
The Journal of pharmacy and pharmacology - 1 Mar 2001
Klaren P H, Hardcastle J, Evans S, Colledge W H, Evans M J, Taylor C J, Hardcastle P T, White S J
Abstract excerpt
In intestinal biopsies from cystic fibrosis (CF) patients acetylcholine fails to elicit a chloride secretion response, and this observation can be explained by a defect in the Ca2+ signalling pathway in CF secretory cells. We tested the hypothesis that in CF intestine, the generation of an intracellular Ca2+ signal upon cholinergic stimulation is absent. A transgenic CF mouse model was used. Electrical...
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