Article

CFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease

2025-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell RNA sequencing (scRNA-seq) studies identified a novel subpopulation of epithelial cells along the rostrocaudal axis of human intestine specifically marked by bestrophin 4 (BEST4) that are enriched for genes regulating pH, GPCR acid-sensing receptors, satiety, cGMP signaling, HCO3 - secretion, ion transport, neuropeptides, and paracrine hormones. Interestingly, BEST4+ cells in the pr...

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Literature Corpus work: 56b5630b-259d-5ef2-b9a4-01194040a5c9
DOI: 10.1101/2025.01.24.634747

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