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Article

K2P TASK-2 and KCNQ1-KCNE3 K+ channels are major players contributing to intestinal anion and fluid secretion.

The Journal of physiology - 1 Feb 2018

Julio-Kalajzić Francisca, Villanueva Sandra, Burgos Johanna, Ojeda Margarita, Cid L Pablo, Jentsch Thomas J, Sepúlveda Francisco V

Abstract excerpt

KEY POINTS: K+ channels are important in intestinal epithelium as they ensure the ionic homeostasis and electrical potential of epithelial cells during anion and fluid secretion. Intestinal epithelium cAMP-activated anion secretion depends on the activity of the (also cAMP dependent) KCNQ1-KCNE3 K+ channel, but the secretory process survives after genetic inactivation of the K+ channel in the mouse. Here we use...

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Source

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Identifiers

PMID: 29143340
DOI: 10.1113/JP275178
PMCID: PMC5792569

Genes

KCNQ1
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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