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Article

Defective cholinergic Cl(-) secretion and detection of K(+) secretion in rectal biopsies from cystic fibrosis patients.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2000

Mall M, Wissner A, Seydewitz H H, Kuehr J, Brandis M, Greger R, Kunzelmann K

Abstract excerpt

Rectal biopsies from cystic fibrosis (CF) patients show defective cAMP-activated Cl(-) secretion and an inverse response of the short-circuit current (I(sc)) toward stimulation with carbachol (CCh). Alternative Cl(-) channels are found in airway epithelia and have been attributed to residual Cl(-) secretion in CF colon. The aim of the present study was to investigate ion conductances causing reversed I(sc) upon...

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Identifiers

PMID: 10762616
DOI: 10.1152/ajpgi.2000.278.4.G617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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