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Article

Molecular mechanisms in the evolution of chronic myelocytic leukemia.

Leukemia & lymphoma - 1 Jul 1992

Cline M J, Jat P S, Foti A

Abstract excerpt

Chronic myelocytic or Ph1-positive acute lymphoblastic leukemias have been analyzed for alterations in a variety of proto-oncogenes and anti-oncogenes implicated in the progression of chronic myeloid leukemia (CML) from its chronic phase to blast crisis. The most frequent genetic change found in disease evolution is an alteration of the p53 gene involving a point mutation, a rearrangement or a deletion. These...

Topics

Blast Crisis
Genes, Retinoblastoma
Genes, p53
Genes, ras
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1493427
DOI: 10.3109/10428199209049779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1493427-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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