Biphenotypic blast crisis of chronic myelogenous leukemia: abnormalities of p53 and retinoblastoma genes.

doi:10.3109/10428199709039046

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Article

Biphenotypic blast crisis of chronic myelogenous leukemia: abnormalities of p53 and retinoblastoma genes.

Leukemia & lymphoma - 1 May 1997

Ishikura H, Yufu Y, Yamashita S, Abe Y, Okamura T, Motomura S, Nishimura J, Nawata H

Abstract excerpt

The molecular mechanisms responsible for progression of chronic myelogenous leukemia (CML) to blast crisis have not been well defined. Blast crisis may be partially related to inactivation of tumor suppressor genes/such as p53 or retinoblastoma (Rb) gene. There is evidence for an association of blast cell phenotypes in CML with alterations of these genes: a strong association of myeloid phenotypes with...

Topics

Blast Crisis
Blotting, Southern
Blotting, Western
Female
Gene Expression
Gene Rearrangement
Genes, Retinoblastoma
Genes, p53
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Middle Aged
Phenotype
Retinoblastoma Protein

Source

Open in PubMed

Identifiers

PMID: 9250829
DOI: 10.3109/10428199709039046

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