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Article

MidA is a putative methyltransferase that is required for mitochondrial complex I function.

Journal of cell science - 15 May 2010

Carilla-Latorre Sergio, Gallardo M Esther, Annesley Sarah J, Calvo-Garrido Javier, Graña Osvaldo, Accari Sandra L, Smith Paige K, Valencia Alfonso, Garesse Rafael, Fisher Paul R, Escalante Ricardo

Abstract excerpt

Dictyostelium and human MidA are homologous proteins that belong to a family of proteins of unknown function called DUF185. Using yeast two-hybrid screening and pull-down experiments, we showed that both proteins interact with the mitochondrial complex I subunit NDUFS2. Consistent with this, Dictyostelium cells lacking MidA showed a specific defect in complex I activity, and knockdown of human MidA in HEK293T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20406883
DOI: 10.1242/jcs.066076

Genes

NDUFS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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