Article
The Dictyostelium model for mitochondrial disease.
Seminars in cell & developmental biology - 1 Feb 2011
Francione Lisa M, Annesley Sarah J, Carilla-Latorre Sergio, Escalante Ricardo, Fisher Paul R
Abstract excerpt
Mitochondrial diseases are a diverse family of genetic disorders caused by mutations affecting mitochondrial proteins encoded in either the nuclear or the mitochondrial genome. By impairing mitochondrial oxidative phosphorylation, they compromise cellular energy production and the downstream consequences in humans are a bewilderingly complex array of signs and symptoms that can affect any of the major organ...
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