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Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair

7 Oct 2021

Abstract excerpt

Preserving genome integrity through repair of DNA damage is critical for human health and defects in these pathways lead to a variety of pathologies, most notably cancer. The social amoeba Dictyostelium discoideum is remarkably resistant to DNA damaging agents and genome analysis reveals it contains orthologs of several DNA repair pathway components otherwise limited to vertebrates. These include the Fanconi...

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PMID: 34692705
DOI: 10.3389/fcell.2021.752175

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