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Article

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.

The Journal of cell biology - 3 Apr 2017

Yeyati Patricia L, Schiller Rachel, Mali Girish, Kasioulis Ioannis, Kawamura Akane, Adams Ian R, Playfoot Christopher, Gilbert Nick, van Heyningen Veronica, Wills Jimi, von Kriegsheim Alex, Finch Andrew, Sakai Juro, Schofield Christopher J, Jackson Ian J, Mill Pleasantine

Abstract excerpt

Cilia assembly and disassembly are coupled to actin dynamics, ensuring a coherent cellular response during environmental change. How these processes are integrated remains undefined. The histone lysine demethylase KDM3A plays important roles in organismal homeostasis. Loss-of-function mouse models of Kdm3a phenocopy features associated with human ciliopathies, whereas human somatic mutations correlate with poor...

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Identifiers

PMID: 28246120
DOI: 10.1083/jcb.201607032
PMCID: PMC5379941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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