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Article

Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production.

The Journal of biological chemistry - 25 Jun 2010

Nistal-Villán Estanislao, Gack Michaela U, Martínez-Delgado Gustavo, Maharaj Natalya P, Inn Kyung-Soo, Yang Heyi, Wang Rong, Aggarwal Aneel K, Jung Jae U, García-Sastre Adolfo

Abstract excerpt

RIG-I (retinoic acid-inducible gene I) and TRIM25 (tripartite motif protein 25) have emerged as key regulatory factors to induce interferon (IFN)-mediated innate immune responses to limit viral replication. Upon recognition of viral RNA, TRIM25 E3 ligase binds the first caspase recruitment domain (CARD) of RIG-I and subsequently induces lysine 172 ubiquitination of the second CARD of RIG-I, which is essential for...

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Source

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Identifiers

PMID: 20406818
DOI: 10.1074/jbc.M109.089912
PMCID: PMC2888438

Genes

TRIM25
MAVS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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