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Article

HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I.

The EMBO journal - 15 Feb 2016

Choi Su Jin, Lee Hyun-Cheol, Kim Jae-Hoon, Park Song Yi, Kim Tae-Hwan, Lee Woon-Kyu, Jang Duk-Jae, Yoon Ji-Eun, Choi Young-Il, Kim Seihwan, Ma JinYeul, Kim Chul-Joong, Yao Tso-Pang, Jung Jae U, Lee Joo-Yong, Lee Jong-Soo

Abstract excerpt

RIG-I is a key cytosolic sensor that detects RNA viruses through its C-terminal region and activates the production of antiviral interferons (IFNs) and proinflammatory cytokines. While posttranslational modification has been demonstrated to regulate RIG-I signaling activity, its significance for the sensing of viral RNAs remains unclear. Here, we first show that the RIG-I C-terminal region undergoes deacetylation...

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Share to DEAD Box Protein 58
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to Mice, Knockout

Share to Protein Processing, Post-Translational

Share to Receptors, Immunologic

Share to RNA, Viral

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Source

Open in PubMed Open full text

Identifiers

PMID: 26746851
DOI: 10.15252/embj.201592586
PMCID: PMC4755110

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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