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Article

Concepts in solid tumor evolution.

Trends in genetics : TIG - 1 Apr 2015

Sidow Arend, Spies Noah

Abstract excerpt

Evolutionary mechanisms in cancer progression give tumors their individuality. Cancer evolution is different from organismal evolution, however, and we discuss where concepts from evolutionary genetics are useful or limited in facilitating an understanding of cancer. Based on these concepts we construct and apply the simplest plausible model of tumor growth and progression. Simulations using this simple model...

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Identifiers

PMID: 25733351
DOI: 10.1016/j.tig.2015.02.001
PMCID: PMC4380537

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Source receipt: pubmed, retrieved 7 Sept 2026.

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