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Article

Cancer evolution: Darwin and beyond.

The EMBO journal - 15 Sept 2021

Vendramin Roberto, Litchfield Kevin, Swanton Charles

Abstract excerpt

Clinical and laboratory studies over recent decades have established branched evolution as a feature of cancer. However, while grounded in somatic selection, several lines of evidence suggest a Darwinian model alone is insufficient to fully explain cancer evolution. First, the role of macroevolutionary events in tumour initiation and progression contradicts Darwin's central thesis of gradualism. Whole-genome...

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Source

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Identifiers

PMID: 34459009
DOI: 10.15252/embj.2021108389
PMCID: PMC8441388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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