Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Models of carcinogenesis: an overview.

Carcinogenesis - 1 Oct 2010

Vineis Paolo, Schatzkin Arthur, Potter John D

Abstract excerpt

At least five coherent models of carcinogenesis have been proposed in the history of cancer research in the last century. Model 1 is mainly centered around mutations, and its main focus is on the chemical environment, radiation and viruses. Model 2 has to do mainly with genome instability and it focuses on familiality. Model 3 is based on non-genotoxic mechanisms, and clonal expansion and epigenetics are its main...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenesis, Genetic
Share to Genomic Instability
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Theoretical

Share to Mutation

Share to Neoplasms

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20430846
DOI: 10.1093/carcin/bgq087
PMCID: PMC3025741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Models of carcinogenesis: an overview.PMID 20430846Read ↗

Somatic mutation theory of carcinogenesis: why it should be dropped and replaced.Semantic proximity Read ↗

Theories of carcinogenesis: an emerging perspective.Semantic proximity Read ↗

A mutational model of carcinogenesis.Semantic proximity Read ↗

What is cancer? Theories on carcinogenesis.Semantic proximity Read ↗

An evolutionary model for initiation, promotion, and progression in carcinogenesisSemantic proximity Read ↗

Towards a systemic paradigm in carcinogenesis: linking epigenetics and genetics.Semantic proximity Read ↗

New hypotheses for cancer generation and progression.Semantic proximity Read ↗

From Molecular Biology to Epithelial CarcinogenesisSemantic proximity Read ↗

The somatic mutation theory of cancer: growing problems with the paradigm?Semantic proximity Read ↗

[Carcinogenesis].Semantic proximity Read ↗

[Molecular mechanisms of carcinogenesis: an outline].Semantic proximity Read ↗

Cancer models, genomic instability and somatic cellular Darwinian evolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.