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Article

Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD.

Autophagy - 1 May 2010

Amarnath Shoba, Flomerfelt Francis A, Costanzo Carliann M, Foley Jason E, Mariotti Jacopo, Konecki Daniel M, Gangopadhyay Anu, Eckhaus Michael, Wong Susan, Levine Bruce L, June Carl H, Fowler Daniel H

Abstract excerpt

Murine T cells exposed to rapamycin maintain flexibility towards Th1/Tc1 differentiation, thereby indicating that rapamycin promotion of regulatory T cells (Tregs) is conditional. The degree to which rapamycin might inhibit human Th1/Tc1 differentiation has not been evaluated. In the presence of...

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Identifiers

PMID: 20404486
DOI: 10.4161/auto.6.4.11811
PMCID: PMC3707503

Genes

STAT1
STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20404486-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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