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Article

Combined administration of a mutant TGF-beta1/Fc and rapamycin promotes induction of regulatory T cells and islet allograft tolerance.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2010

Zhang Wensheng, Zhang Dong, Shen Miaoda, Liu Yun, Tian Yan, Thomson Angus W, Lee W P Andrew, Zheng Xin Xiao

Abstract excerpt

The critical roles of TGF-β in the reciprocal differentiation of tolerance-promoting CD4(+)Foxp3(+) regulatory T cells (Tregs) and proinflammatory Th17 effector cells affect alloimmune reactivity and transplant outcome. We reasoned that a strategy to harness TGF-β and block proinflammatory cytokines would inhibit the differentiation of Th17 cells and strengthen the cadre of Tregs to promote tolerance induction...

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Source

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Identifiers

PMID: 20844194
DOI: 10.4049/jimmunol.1000769
PMCID: PMC3766970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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