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Rapamycin and abundant TCR stimulation are required for the generation of stable human induced regulatory T cells

1 Jan 2020

Abstract excerpt

Abstract Objectives Regulatory T cells (Tregs) are a vital sub‐population of CD4+ T cells with major roles in immune tolerance and homeostasis. Given such properties, the use of regulatory T cells for immunotherapies has been extensively investigated, with a focus on adoptive transfer of ex vivo expanded natural Tregs (nTregs). For immunotherapies, induced Tregs (iTregs), generated in vitro from naïve CD4+ T...

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PMID: 33425354
DOI: 10.1002/cti2.1223

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