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Article

Harnessing autophagy for cell fate control gene therapy.

Autophagy - 1 Jul 2013

Felizardo Tania C, Foley Jason, Steed Kevin, Dropulic Boro, Amarnath Shoba, Medin Jeffrey A, Fowler Daniel H

Abstract excerpt

We hypothesized that rapamycin, through induction of autophagy and promotion of an antiapoptotic phenotype, would permit lentiviral (LV)-based transgene delivery to human T-Rapa cells, which are being tested in phase II clinical trials in the setting of allogeneic hematopoietic cell transplantation. Manufactured T-Rapa cells were exposed to supernatant enriched for a LV vector encoding a fusion protein consisting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23633667
DOI: 10.4161/auto.24639
PMCID: PMC3722316

Genes

DTYMK
SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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