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Article

Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer.

Carcinogenesis - 1 Aug 2010

Frank Bernd, Hoffmeister Michael, Klopp Norman, Illig Thomas, Chang-Claude Jenny, Brenner Hermann

Abstract excerpt

It is well known that approximately 90% of colorectal cancer (CRC) cases originate from the constitutive activation of the canonical Wnt signaling pathway. There is increasing evidence that genetic variation both in Wnt and apoptotic pathway genes affects CRC susceptibility and progression. This population-based case-control study, including 1795 CRC cases and 1805 controls, investigates the association between...

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Source

Identifiers

PMID: 20403915
DOI: 10.1093/carcin/bgq082

Genes

SFRP4
PYGO1
SFRP2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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