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Article

Variation in the Cd3 zeta (Cd247) gene correlates with altered T cell activation and is associated with autoimmune diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2010

Lundholm Marie, Mayans Sofia, Motta Vinicius, Löfgren-Burström Anna, Danska Jayne, Holmberg Dan

Abstract excerpt

Tuning of TCR-mediated activation was demonstrated to be critical for lineage fate in T cell development, as well as in the control of autoimmunity. In this study, we identify a novel diabetes susceptibility gene, Idd28, in the NOD mouse and provide evidence that Cd3zeta (Cd247) constitutes a prime candidate gene for this locus. Moreover, we show that the allele of the Cd3zeta gene expressed in NOD and DBA/2...

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Identifiers

PMID: 20400699
DOI: 10.4049/jimmunol.0904012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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