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Article

Cerebellar proteoglycans regulate sonic hedgehog responses during development.

Development (Cambridge, England) - 1 May 2002

Rubin Joshua B, Choi Yoojin, Segal Rosalind A

Abstract excerpt

Sonic hedgehog promotes proliferation of developing cerebellar granule cells. As sonic hedgehog is expressed in the cerebellum throughout life it is not clear why proliferation occurs only in the early postnatal period and only in the external granule cell layer. We asked whether heparan sulfate proteoglycans might regulate sonic hedgehog-induced proliferation and thereby contribute to the specialized...

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Identifiers

PMID: 11959830
DOI: 10.1242/dev.129.9.2223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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