Article
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.
Proceedings of the National Academy of Sciences of the United States of America - 4 May 2010
Banerjee Arijit, Mikhailova Ellina, Cheley Stephen, Gu Li-Qun, Montoya Michelle, Nagaoka Yasuo, Gouaux Eric, Bayley Hagan
Abstract excerpt
Engineered protein pores have several potential applications in biotechnology: as sensor elements in stochastic detection and ultrarapid DNA sequencing, as nanoreactors to observe single-molecule chemistry, and in the construction of nano- and micro-devices. One important class of pores contains molecular adapters, which provide internal binding sites for small molecules. Mutants of the alpha-hemolysin (alphaHL)...
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