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Article

Calnexin deficiency leads to dysmyelination.

The Journal of biological chemistry - 11 Jun 2010

Kraus Allison, Groenendyk Jody, Bedard Karen, Baldwin Troy A, Krause Karl-Heinz, Dubois-Dauphin Michel, Dyck Jason, Rosenbaum Erica E, Korngut Lawrence, Colley Nansi J, Gosgnach Simon, Zochodne Douglas, Todd Kathryn, Agellon Luis B, Michalak Marek

Abstract excerpt

Calnexin is a molecular chaperone and a component of the quality control of the secretory pathway. We have generated calnexin gene-deficient mice (cnx(-/-)) and showed that calnexin deficiency leads to myelinopathy. Calnexin-deficient mice were viable with no discernible effects on other systems, including immune function, and instead they demonstrated dysmyelination as documented by reduced conductive velocity...

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Identifiers

PMID: 20400506
DOI: 10.1074/jbc.M110.107201
PMCID: PMC2881815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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