Article
The role of innate immunity in acute allograft rejection after lung transplantation.
American journal of respiratory and critical care medicine - 15 Sept 2003
Palmer Scott M, Burch Lauranell H, Davis R Duane, Herczyk Walter F, Howell David N, Reinsmoen Nancy L, Schwartz David A
Abstract excerpt
Although innate immunity is crucial to pulmonary host defense and can initiate immune and inflammatory responses independent of adaptive immunity, it remains unstudied in the context of transplant rejection. To investigate the role of innate immunity in the development of allograft rejection, we assessed the impact of two functional polymorphisms in the toll-like receptor 4 (TLR4) associated with endotoxin...
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