Article
Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation.
Clinical transplantation - 1 Jan 2000
Palmer Scott M, Burch Lauranell H, Mir Saad, Smith Stephen R, Kuo Paul C, Herczyk Walter F, Reinsmoen Nancy L, Schwartz David A
Abstract excerpt
BACKGROUND: Although innate immunity is crucial to host defense against pathogens, the extent to which innate immune mechanisms participate in the rejection of allogenic tissues in humans is unknown. We hypothesize that activation of innate immunity through Toll-like receptors (TLRs) critically regulates the development of renal allograft rejection. We have recently demonstrated decreased acute rejection in lung...
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