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Article

Cyclin A2 mutagenesis analysis: a new insight into CDK activation and cellular localization requirements.

PloS one - 1 Jan 2011

Bendris Nawal, Lemmers Bénédicte, Blanchard Jean-Marie, Arsic Nikola

Abstract excerpt

Cyclin A2 is essential at two critical points in the somatic cell cycle: during S phase, when it activates CDK2, and during the G2 to M transition when it activates CDK1. Based on the crystal structure of Cyclin A2 in association with CDKs, we generated a panel of mutants to characterize the specific amino acids required for partner binding, CDK activation and subcellular localization. We find that CDK1, CDK2,...

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Source

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Identifiers

PMID: 21829545
DOI: 10.1371/journal.pone.0022879
PMCID: PMC3145769

Genes

CDK2
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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