Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells.

The Journal of steroid biochemistry and molecular biology - 1 May 1991

Ashraf J, Kunapuli S, Chilton D, Thompson E B

Abstract excerpt

Cortivazol is a phenylpyrazolo glucocorticoid of high potency and unusual structure. In both wild-type and highly dexamethasone(dex)-resistant clones of the human leukemic cell line CEM, exposure to cortivazol leads to cell death. It has been shown recently that in wild-type CEM cells but not in a dex-resistant, glucocorticoid receptor(GR)-defective clone ICR-27 TK-3, dex induces GR mRNA. To test the hypothesis...

Topics

Cell Survival
Dexamethasone
Drug Resistance
Gene Expression Regulation
Glucocorticoids
Humans
Leukemia-Lymphoma, Adult T-Cell
Mutation
Pregnatrienes
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Glucocorticoid

T-Lymphocytes

Tumor Cells, Cultured

Source

Identifiers

PMID: 2039752
DOI: 10.1016/0960-0760(91)90313-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2039752-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells.PMID 2039752Read ↗

A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA.Semantic proximity Read ↗

A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNASemantic proximity Read ↗

Glucocorticoid Receptors and Resistance to Glucocorticoids in Hematologic MalignanciesSemantic proximity Read ↗

Biochemical evidence that glucocorticoid-sensitive cell lines derived from the human leukemic cell line CCRF-CEM express a normal and a mutant glucocorticoid receptor gene.Semantic proximity Read ↗

Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells.Semantic proximity Read ↗

Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells.Semantic proximity Read ↗

Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression.Semantic proximity Read ↗

Distinct interaction of cortivazol with the ligand binding domain confers glucocorticoid receptor specificity: cortivazol is a specific ligand for the glucocorticoid receptor.Semantic proximity Read ↗

Glucocorticoid-receptor-gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines.Semantic proximity Read ↗

Steroid mediated lysis of lymphoblasts requires the DNA binding region of the steroid hormone receptor.Semantic proximity Read ↗

Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes.Semantic proximity Read ↗

Cytotoxic T lymphocytes and glucocorticoids activate an endogenous suicide process in target cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.