Cytotoxic T lymphocytes and glucocorticoids activate an endogenous suicide process in target cells.

doi:10.1038/327062a0

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Article

Cytotoxic T lymphocytes and glucocorticoids activate an endogenous suicide process in target cells.

Nature - 1 Jan 2000

Ucker D S

Abstract excerpt

Cytotoxic T lymphocytes (CTL) induce a cytolytic process in target cells which, like the glucocorticoid-mediated cytolysis of immature thymocytes, effects a rapid and characteristic degradation of chromosomal DNA. I have explored the possibility that these two lethal processes share a common path...

Topics

Animals
Autolysis
Cell Line
Cytotoxicity, Immunologic
DNA, Neoplasm
Dexamethasone
Drug Resistance
Mice
Mice, Inbred BALB C
Mutation
T-Lymphocytes, Cytotoxic
Thymoma

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