Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid diversification of cell signaling phenotypes by modular domain recombination.

Science (New York, N.Y.) - 16 Apr 2010

Peisajovich Sergio G, Garbarino Joan E, Wei Ping, Lim Wendell A

Abstract excerpt

Cell signaling proteins are often modular, containing distinct catalytic and regulatory domains. Recombination of such biological modules has been proposed to be a major source of evolutionary innovation. We systematically analyzed the phenotypic diversity of a signaling response that results from domain recombination by using 11 proteins in the yeast mating pathway to construct a library of 66 chimeric domain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Gene Duplication
Share to Genes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Reporter

Share to Mitogen-Activated Protein Kinases

Share to Peptide Library

Share to Protein Precursors

Share to Receptors, Mating Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 20395511
DOI: 10.1126/science.1182376
PMCID: PMC2975375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid diversification of cell signaling phenotypes by modular domain recombination.PMID 20395511Read ↗

Signals: tinkering with domains.Semantic proximity Read ↗

The low cost of recombination in creating novel phenotypes: Recombination can create new phenotypes while disrupting well-adapted phenotypes much less than mutation.Semantic proximity Read ↗

Offset recombinant PCR: a simple but effective method for shuffling compact heterologous domains.Semantic proximity Read ↗

Generating combinatorial diversity via engineered V(D)J-like recombination in Saccharomyces cerevisiaeSemantic proximity Read ↗

Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity.Semantic proximity Read ↗

Effects of recombination on complex regulatory circuits.Semantic proximity Read ↗

Sexual recombination and the power of natural selection.Semantic proximity Read ↗

Evolutionary repair: Changes in multiple functional modules allow meiotic cohesin to support mitosis.Semantic proximity Read ↗

Plant Evolution: Evolving Antagonistic Gene Regulatory Networks.Semantic proximity Read ↗

Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions.Semantic proximity Read ↗

Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism.Semantic proximity Read ↗

Relationship between gene duplicability and diversifiability in the topology of biochemical networks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.