Article
Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism.
Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2004
Liu Yang, Gerstein Mark, Engelman Donald M
Abstract excerpt
Recombination of evolutionarily unrelated domains is a mechanism often used by evolution to produce variety in soluble proteins. By using a classification of polytopic transmembrane domains into families, we examined integral membrane proteins for evidence of this mechanism. Surprisingly, we foun...
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