Article
Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism.
Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2004
Liu Yang, Gerstein Mark, Engelman Donald M
Abstract excerpt
Recombination of evolutionarily unrelated domains is a mechanism often used by evolution to produce variety in soluble proteins. By using a classification of polytopic transmembrane domains into families, we examined integral membrane proteins for evidence of this mechanism. Surprisingly, we found that domain recombination is not common for the transmembrane regions of membrane proteins, a majority of integral...
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