Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma.

The British journal of psychiatry : the journal of mental science - 1 Apr 2013

Collip Dina, Myin-Germeys Inez, Wichers Marieke, Jacobs Nele, Derom Catherine, Thiery Evert, Lataster Tineke, Simons Claudia, Delespaul Philippe, Marcelis Machteld, van Os Jim, van Winkel Ruud

Abstract excerpt

BACKGROUND: FK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma. AIMS: To examine the role of FKBP5-trauma interactions in the partly stress-related psychosis phenotype. METHOD: In 401 general population twins, four functional polymorphisms were examined in models of psychosis and cortisol, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Gene-Environment Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrocortisone

Share to Psychotic Disorders

Share to Saliva

Share to Siblings

Share to Tacrolimus Binding Proteins

Share to Wounds and Injuries

Source

Identifiers

PMID: 23429203
DOI: 10.1192/bjp.bp.112.115972

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma.PMID 23429203Read ↗

The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls.Semantic proximity Read ↗

Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide.Semantic proximity Read ↗

Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder.Semantic proximity Read ↗

Maternal posttraumatic stress and FKBP5 Genotype interact to predict trauma-related symptoms in preschool-age offspring.Semantic proximity Read ↗

Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis.Semantic proximity Read ↗

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study.Semantic proximity Read ↗

Childhood trauma as a cause of psychosis: linking genes, psychology, and biology.Semantic proximity Read ↗

The emerging role of the FKBP5 gene polymorphisms in vulnerability-stress model of schizophrenia: further evidence from a Serbian population.Semantic proximity Read ↗

Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.Semantic proximity Read ↗

Genetic Contributors to PTSD: the Role of SNVs, Gene Interactions and Haplotypes for Developing PTSD Prevention Measures. A Comprehensive Review.Semantic proximity Read ↗

FKBP5 genotype interacts with early life trauma to predict heavy drinking in college students.Semantic proximity Read ↗

Interaction between FKBP5 polymorphisms and childhood trauma on depressive symptoms in Chinese adolescents: The moderating role of resilience.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.