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Article

Signaling Pathways in Bone Development and Their Related Skeletal Dysplasia

21 Apr 2021

Abstract excerpt

Bone development is a tightly regulated process. Several integrated signaling pathways including HH, PTHrP, WNT, NOTCH, TGF-β, BMP, FGF and the transcription factors SOX9, RUNX2 and OSX are essential for proper skeletal development. Misregulation of these signaling pathways can cause a large spectrum of congenital conditions categorized as skeletal dysplasia. Since the signaling pathways involved in skeletal...

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PMID: 33919228
DOI: 10.3390/ijms22094321

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