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Loss of Notch signaling in skeletal stem cells enhances bone formation with aging

27 Sept 2023

Abstract excerpt

Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental transformation are largely unknown. Single-cell RNA sequencing revealed that Notch signaling becomes elevated in SSPCs during aging. To examine the role of increased Notch...

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PMID: 37752132
DOI: 10.1038/s41413-023-00283-8

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