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The Developmental Basis of Skeletal Cell Differentiation and the Molecular Basis of Major Skeletal Defects

15 Aug 2008

Abstract excerpt

Vertebrate skeletal differentiation retains elements from simpler phyla, and reflects the differentiation of supporting tissues programmed by primary embryonic development. This developmental scheme is driven by homeotic genes expressed in sequence, with subdivision of skeletal primordia driven by a combination of seven transmembrane-pass receptors responding to Wnt-family signals, and by bone morphogenetic...

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PMID: 18710437
DOI: 10.1111/j.1469-185x.2008.00048.x

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