IL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin.

doi:10.1097/QAD.0b013e3283471cae

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Article

IL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin.

AIDS (London, England) - 15 May 2011

Rallón Norma I, Soriano Vincent, Naggie Susanna, Restrepo Clara, Goldstein David, Vispo Eugenia, McHutchison John, Benito José M

Abstract excerpt

BACKGROUND: A single nucleotide polymorphism (SNP) upstream of the IL28B gene (rs12979860) predicts sustained virological response (SVR) to peginterferon-ribavirin therapy in chronic hepatitis C patients. There is scarce information regarding the influence of this IL28B SNP on early viral kinetics during therapy, particularly in patients coinfected with HIV, in whom treatment response is lower than in hepatitis C...

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PMID: 21505315
DOI: 10.1097/QAD.0b013e3283471cae
PMCID: PMC4892378

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