Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4.

doi:10.1002/hep.24683

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Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4.

Hepatology (Baltimore, Md.) - 1 Feb 2012

De Nicola Stella, Aghemo Alessio, Rumi Maria Grazia, Galmozzi Enrico, Valenti Luca, Soffredini Roberta, De Francesco Raffaele, Prati Gian Maria, D'Ambrosio Roberta, Cheroni Cristina, Donato Maria Francesca, Colombo Massimo

Abstract excerpt

UNLABELLED: Single nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) region are the strongest baseline predictors of a sustained virologic response (SVR) to peg-interferon (PegIFN) and ribavirin (Rbv) in patients with hepatitis C virus (HCV) genotype 1 infection. Whether this holds true for HCV-4 patients too is unknown. The aim was to investigate the predictive power of the rs12979860 IL28B SNP...

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PMID: 21932415
DOI: 10.1002/hep.24683

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