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Article

Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine.

The Journal of clinical investigation - 1 May 2010

Corti Davide, Suguitan Amorsolo L, Pinna Debora, Silacci Chiara, Fernandez-Rodriguez Blanca M, Vanzetta Fabrizia, Santos Celia, Luke Catherine J, Torres-Velez Fernando J, Temperton Nigel J, Weiss Robin A, Sallusto Federica, Subbarao Kanta, Lanzavecchia Antonio

Abstract excerpt

The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been used to classify influenza viruses into subtypes (H1-H16). The neutralizing antibody response to influenza virus is thought to be specific for a few antigenically related isolates within a given subtype. However, while heterosubtypic antibodies capable of...

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Identifiers

PMID: 20389023
DOI: 10.1172/JCI41902
PMCID: PMC2860935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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