Article
A non-VH1-69 heterosubtypic neutralizing human monoclonal antibody protects mice against H1N1 and H5N1 viruses.
PloS one - 1 Jan 2012
De Marco Donata, Clementi Nicola, Mancini Nicasio, Solforosi Laura, Moreno Guisella J, Sun Xiangjie, Tumpey Terrence M, Gubareva Larisa V, Mishin Vasiliy, Clementi Massimo, Burioni Roberto
Abstract excerpt
Influenza viruses are among the most important human pathogens and are responsible for annual epidemics and sporadic, potentially devastating pandemics. The humoral immune response plays an important role in the defense against these viruses, providing protection mainly by producing antibodies directed against the hemagglutinin (HA) glycoprotein. However, their high genetic variability allows the virus to evade...
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