Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>Sleeping Beauty</i> –Mediated Somatic Mutagenesis Implicates <i>CSF1</i> in the Formation of High-Grade Astrocytomas

13 Apr 2010

Abstract excerpt

The Sleeping Beauty (SB) transposon system has been used as an insertional mutagenesis tool to identify novel cancer genes. To identify glioma-associated genes, we evaluated tumor formation in the brain tissue from 117 transgenic mice that had undergone constitutive SB-mediated transposition. Upon analysis, 21 samples (18%) contained neoplastic tissue with features of high-grade astrocytomas. These tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to MicroRNA in disease regulation
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20388773
DOI: 10.1158/0008-5472.can-09-4674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>Sleeping Beauty</i> –Mediated Somatic Mutagenesis Implicates <i>CSF1</i> in the Formation of High-Grade AstrocytomasPMID 20388773Read ↗

Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cellsSemantic proximity Read ↗

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of GlioblastomaSemantic proximity Read ↗

Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal TumorsSemantic proximity Read ↗

Transposon mutagenesis disentangles osteosarcoma genetic drivers.Semantic proximity Read ↗

Childhood cancer mutagenesis caused by a domesticated DNA transposaseSemantic proximity Read ↗

Genetic Signature of Histiocytic Sarcoma Revealed by a Sleeping Beauty Transposon Genetic Screen in MiceSemantic proximity Read ↗

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects.Semantic proximity Read ↗

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.Semantic proximity Read ↗

A DNA transposon-based approach to validate oncogenic mutations in the mouse.Semantic proximity Read ↗

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.Semantic proximity Read ↗

Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis.Semantic proximity Read ↗

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.