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Article

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects.

Nature genetics - 1 Sept 2000

Reilly K M, Loisel D A, Bronson R T, McLaughlin M E, Jacks T

Abstract excerpt

Astrocytomas are the leading cause of brain cancer in humans. Because these tumours are highly infiltrative, current treatments that rely on targeting the tumour mass are often ineffective. A mouse model for astrocytoma would be a powerful tool for dissecting tumour progression and testing therapeutics. Mouse models of astrocytoma have been designed to express oncogenic proteins in astrocytes, but have had...

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Identifiers

PMID: 10973261
DOI: 10.1038/79075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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