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Article

Mutations of TFPI-binding exosites on factor VII cause bleeding phenotypes in factor VII deficiency.

Blood advances - 22 Nov 2022

Seanoon Karnsasin, Payongsri Panwajee, Vivithanaporn Pornpun, Sirachainan Nongnuch, Chuansumrit Ampaiwan, Hongeng Suradej, Tanratana Pansakorn

Abstract excerpt

Tissue factor (TF) pathway inhibitor (TFPI) is a Kunitz-type anticoagulation protein that inhibits activated factor VII (FVIIa)/TF complex. Incidentally, many different F7 gene variants, including TFPI-binding exosite mutations, have been reported in patients with congenital FVII deficiency and clinical bleeding variabilities. Here, TFPI-binding exosites (R147 and K192) on FVII zymogen were selectively disrupted...

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Identifiers

PMID: 35973191
DOI: 10.1182/bloodadvances.2022007560
PMCID: PMC9661381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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